CFTR mRNA compositions and related methods and uses

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 9713626
APP PUB NO 20160106772A1
SERIAL NO

14876071

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Abstract

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Pharmaceutical compositions comprising an mRNA-loaded nanoparticle, wherein the mRNA is an in vitro transcribed mRNA and has a coding sequence at least 80% identical to SEQ ID NO: 3, and wherein the mRNA encodes a human cystic fibrosis transmembrane conductance regulator (CFTR) protein comprising the amino acid sequence of SEQ ID NO:1 are provided. The present invention is particularly useful for treating cystic fibrosis.

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Patent Owner(s)

Patent OwnerAddress
TRANSLATE BIO INC200 WEST STREET WALTHAM MA 02451

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
DeRosa, Frank Lexington, US 261 2650
Guild, Braydon Charles Concord, US 84 2223
Heartlein, Michael Lexington, US 223 2893
Plank, Christian Wessling, DE 31 688
Rudolph, Carsten Krailling, DE 43 704
Smith, Lianne Lexington, US 15 198

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