Reducing intron retention

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United States of America Patent

PATENT NO 9714422
SERIAL NO

15148303

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Abstract

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Disclosed herein are methods, compositions, polynucleic acid polymers, assays, and kits for inducing processing of a partially processed mRNA transcript to remove a retained intron to produce a fully processed mRNA transcript that encodes a full-length functional form of a protein. Also described herein are methods and compositions for treating a disease or condition characterized by impaired production of a full-length functional form of a protein or for treating a disease or condition characterized by a defective splicing in a subject.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF SOUTHAMPTONUNIVERSITY ROAD SOUTHAMPTON HAMPSHIRE SO17 1BJ

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Kralovicova, Jana Southampton, GB 10 151
Vorechovsky, Igor Southampton, GB 12 162

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