Crystal form of dabigatran etexilate mesylate and preparation method and use thereof

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United States of America Patent

PATENT NO 9718802
APP PUB NO 20170073327A1
SERIAL NO

15123378

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Abstract

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The present invention relates to novel crystal forms M and N of dabigatran etexilate mesylate and preparation method and uses thereof, wherein the X-Ray powder diffractogram of the crystal form M has characteristic peaks at the following 2θ diffraction angles: 5.7±0.2°, 6.2±0.2°, 11.2±0.2°, 12.4±0.2°, 18.2±0.2°, 21.4±0.2°, 21.8±0.2° and 23.6±0.2°; and the X-Ray powder diffractogram of the crystal form N has characteristic peaks at the following 2θ diffraction angles: 6.0±0.2°, 11.8±0.2°, 18.2±0.2°, 21.6±0.2°, 24.4±0.2°, 27.7±0.2° and 29.7±0.2°. The crystal forms of the present invention have excellent properties in the aspects of leaching time, biological release, chemical stability and processing adaptability.

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Patent Owner(s)

Patent OwnerAddress
ZHEJIANG HISUN PHARMACEUTICAL CO LTDJIAOJIANG DISTRICT OF TAIZHOU CITY ZHEJIANG PROVINCE 318000 ROAD OUTSIDE NO 46 TAIZHOU CITY ZHEJIANG PROVINCE 318000

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chai, Jian Taizhou, CN 9 1
Chen, Zhi Taizhou, CN 223 2316
Liu, Chuan Taizhou, CN 153 746
Luo, Hairong Taizhou, CN 3 8
Xu, Jinyi Taizhou, CN 2 0
Yang, Zhiqing Taizhou, CN 12 8
Zhang, Liang Taizhou, CN 689 3734
Zhang, Xiangyang Taizhou, CN 36 875
Zhang, Zhaozhao Taizhou, CN 2 0

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