Cells for producing recombinant iduronate-2-sulfatase
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United States of America Patent
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Aug 1, 2017
Grant Date -
Feb 25, 2016
app pub date -
Aug 21, 2015
filing date -
Jun 29, 2012
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Abstract
The present invention provides, among other things, methods and compositions for production of recombinant I2S protein with improved potency and activity using cells co-express I2S and FGE protein. In some embodiments, cells according to the present invention are engineered to simultaneously over-express recombinant I2S and FGE proteins. Cells according to the invention are adaptable to various cell culture conditions. In some embodiments, cells of the present invention adaptable to a large-scale suspension serum-free culture.
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