Massive parallel method for decoding DNA and RNA

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United States of America Patent

PATENT NO 9719139
SERIAL NO

15380311

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Abstract

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This invention provides methods for attaching a nucleic acid to a solid surface and for sequencing nucleic acid by detecting the identity of each nucleotide analog after the nucleotide analog is incorporated into a growing strand of DNA in a polymerase reaction. The invention also provides nucleotide analogs which comprise unique labels attached to the nucleotide analog through a cleavable linker, and a cleavable chemical group to cap the —OH group at the 3′-position of the deoxyribose.

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Patent Owner(s)

Patent OwnerAddress
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK412 LOW MEMORIAL LIBRARY 535 WEST 116TH STREET MAIL CODE 4308 NEW YORK NY 10027

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Edwards, John Robert St. Louis, US 32 1853
Itagaki, Yasuhiro New York, US 32 1609
Ju, Jingyue Englewood Cliffs, US 128 6641
Li, Zengmin Flushing, US 56 2637

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