Methods for producing high-fidelity autologous idiotype vaccines
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United States of America Patent
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Aug 8, 2017
Grant Date -
Sep 17, 2015
app pub date -
Aug 30, 2013
filing date -
Aug 31, 2012
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Abstract
The present invention concerns methods for selecting and producing idiotype vaccines, and in particular methods for selecting and producing an idiotype vaccine for treatment of a B-cell derived malignancy in a subject based on the clonal profile (clonotype) of the malignancy; a method for producing an updated idiotype vaccine matched to a B-cell derived malignancy exhibiting a shifting clonal profile; and the high-fidelity idiotype vaccines produced using the methods. The invention also includes idiotype vaccines produced using the described methods and methods of treating B-cell derived malignancies using the produced vaccines.
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