Treatment of cereal flour and semolina for consumption by celiac patients

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United States of America Patent

PATENT NO 9730458
SERIAL NO

12312240

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Abstract

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The present invention relates to the use of an enzymatic method for treating flour, semolina and protein extracts derived from cereals known to stimulate a pathological immune response in patients affected by Celiac Disease (CD). Said treatment drastically reduces or completely eliminates the toxicity of gluten or similar products derived from other cereals. The method uses the catalytic activity of microbial transglutaminase and, in particular, its ability to bind proteins in cereal flour or semolina to an alkylated (C1-C4) derivative of lysine. After the treatment said proteins extracted from flour show a substantially lowered immuno-stimulatory activity in celiac patients T lymphocytes.

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Patent Owner(s)

Patent OwnerAddress
CONSIGLIO NAZIONALE DELLE RICERCHEPIAZZALE ALDO MORO 7 00185 ROMA 00185

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Gianfrani, Carmela Naples, IT 2 0
Rossi, Mauro Avellino, IT 15 174
Siciliano, Rosa Anna Avellino, IT 1 0

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