Process for preparing vaccine composition
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United States of America Patent
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Aug 15, 2017
Grant Date -
Apr 17, 2014
app pub date -
Apr 20, 2012
filing date -
Apr 21, 2011
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Abstract
A method of preparing a composition comprising one or more antigens adsorbed to an amino acid wherein said method comprises: (i) mixing a solution of one or more antigens with a solution of the amino acid in an aqueous acid whilst neutralizing the mixture of solutions, thereby forming an adsorbate comprising the one or more antigens and the amino acid; (ii) separating the adsorbate into a desired buffer by cross-flow filtration thereby forming said composition; and (iii) recovering said composition; wherein steps (i) to (iii) are performed in a sterile environment and within a closed system.
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