Treatment of paroxysmal nocturnal hemoglobinuria patients by an inhibitor of complement

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United States of America Patent

PATENT NO 9732149
SERIAL NO

15284015

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Abstract

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Eculizumab, a humanized monoclonal antibody against C5 that inhibits terminal complement activation, showed activity in a preliminary 12-week open-label trial in a small cohort of patients with paroxysmal nocturnal hemoglobinuria (PNH). The present study examined whether chronic eculizumab therapy could reduce intravascular hemolysis, stabilize hemoglobin levels, reduce transfusion requirements, and improve quality of life in a double-blind, randomized, placebo-controlled, multi-center global Phase III trial. It has been found that eculizumab stabilized hemoglobin levels, decreased the need for transfusions, and improved quality of life in PNH patients via reduced intravascular hemolysis. Chronic eculizumab treatment appears to be a safe and effective therapy for PNH.

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Patent Owner(s)

Patent OwnerAddress
ALEXION PHARMACEUTICALS INC121 SEAPORT BOULEVARD BOSTON MA 02210

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bell, Leonard Woodbridge, US 34 555
Evans, Mark J Radnor, US 17 452
Rother, Russell P Oklahoma City, US 62 897

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