General strategy for antibody library screening

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United States of America Patent

PATENT NO 9733240
APP PUB NO 20140357514A1
SERIAL NO

14361358

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Abstract

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A generally applicable method for the selective covalent attachment of a reporter molecule to a replicating entity that allows one to obtain specific binders from a single round of library screening is disclosed. For example, selective biotinylation of phage particles and yeast cells displaying a binder to any given target can be achieved via application of a coupled enzyme reaction that includes a peroxidase, an oxidase and a catalase.

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Patent Owner(s)

Patent OwnerAddress
MERCK PATENT GMBH64293 DARMSTADT

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Becker, Stefan Darmstadt, DE 87 627
Heiseler, Tim Rossdorf, DE 1 0
Kolmar, Harald Muehltal-Trautheim, DE 11 66
Maass, Alexander Darmstadt, DE 27 390

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