Methods and compositions related to modulators of eukaryotic cells

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United States of America Patent

PATENT NO 9738719
SERIAL NO

14424663

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Abstract

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Methods for Identifying protein modulators of eukaryotic cells by expressing a combinatorial library of potential agonists inside a eukaryotic cell and then directly selecting for an agonist of a target molecule. Some methods involve co-culturing a cell expressing a combinatorial library of potential agonists and a second cell, and then selecting agents that modulate a phenotype of or a desired cellular response in the second cell. Preferably, the agonists are antibodies introduced into and expressed in the starting cells, such as agonist anti-EpoR, anti-TpoR, or G-CSFR antibodies. Also disclosed are methods for selecting from combinatorial antibody libraries bispecific antibodies that can regulate cell phenotypes.

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Patent Owner(s)

Patent OwnerAddress
SCRIPPS RESEARCH INSTITUTE THE10550 NORTH TORREY PINES ROAD LA JOLLA CA 92037

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Lerner, Richard A La Jolla, US 114 5542
Wilson, Ian A La Jolla, US 27 342
Zhang, Hongkai San Diego, US 15 22

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