Herpes simplex virus (HSV) with modified tropism, uses and process of preparation thereof

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United States of America Patent

PATENT NO 9744199
SERIAL NO

14864098

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A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion; the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC; uses of the modified HSV and a process of the preparation thereof are also disclosed.

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Patent Owner(s)

Patent OwnerAddress
ALMA MATER STUDIORUM-UNIVERSITÀ DI BOLOGNABOLOGNA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Campadelli, Gabriella Bologna, IT 2 11
Menotti, Laura Bologna, IT 3 28

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