Method for identifying antibiotic targets

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United States of America Patent

PATENT NO 9745572
SERIAL NO

14071615

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Abstract

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Provided are methods for identifying differentially represented genes, the method comprising the steps of generating a pool of mutant bacteria by transposon mutagenesis with an activating transposon (TnA), wherein the TnA comprises a promoter such that transposon insertion into bacterial DNA increases the transcription of a gene at or near the insertion site; growing bacteria from the mutant pool in the presence of different amounts of said antibiotic to produce two or more test cultures; and comparing the distribution of TnA insertions between test cultures.

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Patent Owner(s)

Patent OwnerAddress
DISCUVA LIMITEDCAMBRIDGE CB4 0WE

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Turner, Arthur Keith Cambridge, GB 11 44
Williams, David Hugh Cambridge, GB 24 296

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