Targeted therapies for cancer

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United States of America Patent

PATENT NO 9750741
SERIAL NO

14776552

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Abstract

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Methods of selecting a chemotherapy regimen for treatment of cancer in a patient are disclosed. A patient genetic sample from a bilary cancer such as cholangiocarcinoma is analyzed for a mutation in ERRFI1 and a chemotherapeutic agent is selected as a result of the analysis. If a mutation in ERRFI1 is present, treatment with an inhibitor of Epidermal Growth Factor Receptor (EGFR) is shown to have inhibitory effects on tumor growth. In this manner, the chemotherapy regimen is targeted to a given mutation in a patient's cancer.

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Patent Owner(s)

Patent OwnerAddress
MAYO FOUNDATION FOR MEDICAL EDUCATION AND RESEARCH200 FIRST STREET S W ROCHESTER MN 55905

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Borad, Mitesh Jivraj Scottsdale, US 2 0
Carpten, John Phoenix, US 9 29
Craig, David Phoenix, US 35 428

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