Alpha-enolase specific antibodies and method of use in immune diseases

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United States of America Patent

PATENT NO 9750804
SERIAL NO

14580127

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Abstract

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A method for treating an inflammatory disease or an immune disorder includes administering to a subject in need of such treatment an antagonist against ENO1. The antagonist binds ENO1 and inhibits ENO1 plasminogen receptor activity. The antagonist may be an anti-human ENO1 antibody, or an scFv, Fab, or F(ab)2 fragment thereof, that specifically binds to human ENO1 (GenBank: AAH50642.1) for the treatment of an inflammatory disease or an immune disorder, which may be multiple sclerosis, rheumatoid arthritis, Crohn's disease, ulcerative colitis, systemic Lupus erythematosus, chronic obstructive pulmonary disease (COPD), asthma, allergy, psoriasis, type 1 diabetes mellitus, artherosclerosis or osteoporosis.

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Patent OwnerAddress
NATIONAL HEALTH RESEARCH INSTITUTES35 KEYAN ROAD ZHUNAN TOWN 35053

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chang, Mingl New Taipei, TW 1 2
Chen, Li-Tzong Miaoli County, TW 9 64
Chen, Shyi-Jou New Taipei, TW 1 2
Chia, Wei-Tso New Taipei, TW 2 2
Liu, Ko-Jiunn Miaoli County, TW 18 27
Shih, Neng-Yao Miaoli County, TW 12 27
Tsai, Shih-Chong New Taipei, TW 8 9
Tseng, Shih-Chi New Taipei, TW 5 5
Wang, Hsin-Yun New Taipei, TW 2 3
Yuan, Ta-Tung New Taipei, TW 14 33

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