Method for producing 1,4-benzoxazine compound
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United States of America Patent
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Sep 5, 2017
Grant Date -
Dec 15, 2016
app pub date -
Jul 8, 2016
filing date -
Aug 8, 2012
priority date (Note) -
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Abstract
The present invention provides an industrially advantageous method for producing a 1,4-benzoxazine compound useful as a medicine while avoiding safety and health risks. Specifically, the present invention provides a method for producing a 1,4-benzoxazine compound [A], which comprises the three steps in the following scheme, namely, a step of converting the amino group at 7-position in a compound [a] into a dimesylamino group, a step of coupling a compound [b] with a boronic acid compound, and a step of converting the 7-position in a compound [c] into a monomesylamino group.
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