Synthesis of duocarmycin analogues

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United States of America Patent

PATENT NO 9765077
APP PUB NO 20160347753A1
SERIAL NO

14725252

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Abstract

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A novel Fmoc protected duocarmycin subunit and utilization as a reagent in solid phase protein synthesis methodology. Also provided is a novel method of solid phase peptide synthesis, and in particular a method for the production of novel intermediates and novel monomeric and extended duocarmycin analogues having amino acid substituents.

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Patent Owner(s)

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UNIVERSITY OF EAST ANGLIANORWICH NORFOLK NR4 7TJ

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Howell, Lesley A Norwich, GB 1 0
Searcey, Mark Norwich, GB 6 3
Stephenson, Michael J Norwich, GB 9 353

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