Antibody constructs for CDH19 and CD3

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United States of America Patent

PATENT NO 9765157
SERIAL NO

14815861

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Abstract

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The present invention provides a bispecific antibody construct comprising a first human binding domain which binds to human CDH19 on the surface of a target cell and a second binding domain which binds a human CD3 on the surface of a T cell. Moreover, the invention provides a polynucleotide encoding the antibody construct, a vector comprising the polynucleotide and a host cell transformed or transfected with the polynucleotide or vector. Furthermore, the invention provides a process for the production of the antibody construct of the invention, a medical use of the antibody construct in the treatment of melanoma, and a kit comprising the antibody construct.

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Patent Owner(s)

Patent OwnerAddress
AMGEN RESEARCH (MUNICH) GMBH81477 MÜNCHEN

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Blumel, Claudia Munich, DE 2 30
Hoffmann, Patrick Munich, DE 69 1097
Kufer, Peter Munich, DE 106 2671
Lutterbüse, Ralf Munich, DE 38 334
Nahrwold, Elisabeth Munich, DE 21 201
Pan, Zheng Fremont, US 23 88
Raum, Tobias Munich, DE 92 1685
Wickramasinghe, Dineli San Francisco, US 14 106
Xiao, Shouhua Foster City, US 14 81

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