Bimolecular protease-based biosensor

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United States of America Patent

PATENT NO 9772328
SERIAL NO

15021494

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Abstract

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A biosensor comprises first and second molecular components and is capable of displaying protease activity in response to a binding event mediated by first and second binding partners of the biosensor. The first and second binding partners may bind each other directly or may both bind a target molecule. At least the first molecular component comprises an autoinhibited protease, whereby the binding event switches the protease frora an autoinhibited inactive state to a protease active state. The second molecular component may activate the protease of the first molecular component by binding a cross-binder which releases the autoinhibitor or by cleaving a linker which releases the autoinhibitor. The first and second molecular components may both have autoinhibited proteases which reciprocally activate each other.

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Patent Owner(s)

Patent OwnerAddress
THE UNIVERSITY OF QUEENSLANDQUEENSLAND

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alexandrov, Kirill St. Lucia, AU 8 9
Stein, Viktor St. Lucia, AU 4 3

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