Thermal cycler for PCR

Number of patents in Portfolio can not be more than 2000

United States of America Patent

PATENT NO 9776187
APP PUB NO 20080314431A1
SERIAL NO

12229404

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Abstract

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An instrument for performing highly accurate PCR employing an assembly, a heated cover, and an internal computer, is provided. The assembly is made up of a sample block, a number of Peltier thermal electric devices, and a heat sink, clamped together. A control algorithm manipulates the current supplied to thermoelectric coolers such that the dynamic thermal performance of a block can be controlled so that pre-defined thermal profiles of sample temperature can be executed. The sample temperature is calculated instead of measured using a design specific model and equations. The control software includes calibration diagnostics which permit variation in the performance of thermoelectric coolers from instrument to instrument to be compensated for such that all instruments perform identically. The block/heat sink assembly can be changed to another of the same or different design. The assembly carries the necessary information required to characterize its own performance in an on-board memory device, allowing the assembly to be interchangeable among instruments while retaining its precision operating characteristics.

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Patent Owner(s)

Patent OwnerAddress
APPLIED BIOSYSTEMS LLC850 LINCOLN CENTRE DRIVE FOSTER CITY CA 94404

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Atwood, John G West Redding, US 27 1170
Fawcett, Adrian Pleasanton, US 45 807
Ferrara, Keith S Stratford, US 11 236
Hetherington, Paul M Goldens Bridge, US 8 162
Noreiks, Richard W Stratford, US 9 639
Olsen, Douglas E New Fairfield, US 8 162
Widomski, John R Shelton, US 8 162
Wittmer, Charles M Trumbull, US 13 186

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