Small molecule CD4 mimetics and uses thereof

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United States of America Patent

PATENT NO 9776963
SERIAL NO

13128549

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Abstract

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The invention provides for compounds of formula I: wherein Z is absent or (CRARB)nW; each RA and RB is independently (i) H, alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, heteroaralkyl, haloalkyl, each of which may be optionally substituted; (ii) OH, ORc, NH2, NHRc, NRcRc, SH, S(O)mRc; or (iii) RA and RB together form C(O); W is absent, C(O), C(O)O, C(O)NRcRc, O, S(O)m, or NRcRc; Y is an optionally substituted heterocyclic, optionally substituted heteroaryl, optionally substituted cycloalkyl, optionally substituted aryl, or NRXRY; wherein Rx and Ry are each independently H, alkyl or aryl; X1 is selected from the group consisting of halogen, methyl, and hydroxyl; X2 is a halogen; each Rc is independently alkyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, aralkyl, or heteroaralkyl, each of which may be optionally substituted; m is O, 1, or 2; and n is 1, 2, 3, 4, 5, or 6; and pharmaceutically acceptable salts thereof.

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Patent Owner(s)

  • BRYN MAWR COLLEGE;THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK;DANA-FARBER CANCER INSTITUTE, INC.;THE JOHNS HOPKINS UNIVERSITY;THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Courter, Joel R Glen Mills, US 17 406
Freire, Ernesto Baltimore, US 25 84
Hendrickson, Wayne A New York, US 11 28
LaLonde, Judith M Havertown, US 4 4
Le-Khac, Matthew Brooklyn, US 3 4
Madani, Navid Newton, US 4 10
Ng, Danny Daly City, US 7 132
Princiotto, Amy M Attleboro, US 4 4
Schön, Arne Baltimore, US 1 0
Smith,, III Amos B Merion, US 32 84
Sodroski, Joseph G Medford, US 21 296
Soeta, Takahiro Ishikawa, JP 2 9

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