Engineered antibody for inhibition of fibrosis

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United States of America Patent

PATENT NO 9777055
SERIAL NO

14391585

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Abstract

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A chimeric, humanized or single-chain antibody contains a light chain variable region containing the complementarity determining regions of SEQ ID NO: 1, SEQ ID NO:2 and SEQ ID NO:3, and a heavy chain variable region containing the complementarity determining regions SEQ ID NO:4, SEQ ID NO:5 and SEQ ID NO:6. The antibody or antibody fragment thereof is capable of binding the C-terminal telopeptide of the α2(I) chain of human collagen I, and is useful in the treatment of diseases or disorders associated with excessive collagen fibril.

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Patent Owner(s)

Patent OwnerAddress
THOMAS JEFFERSON UNIVERSITY1020 WALNUT STREET PHILADELPHIA PA 19107

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Fertala, Andrzej Voorhees, US 12 82
Steplewski, Andrzej Phoenixville, US 5 4

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