Capsular polysaccharide solubilisation and combination vaccines

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United States of America Patent

PATENT NO 9782467
SERIAL NO

12321434

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Abstract

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Precipitated bacterial capsular polysaccharides can be efficiently re-solubilized using alcohols as solvents. The invention provides a process for purifying a bacterial capsular polysaccharide, comprising the steps of (a) precipitation of said polysaccharide, followed by (b) solubilization of the precipitated polysaccharide using ethanol. CTAB can be used for step (a). The material obtained, preferably following hydrolysis and sizing, can be conjugated to a carrier protein and formulated as a vaccine. Also, in vaccines comprising saccharides from both serogroups A and C, the invention provides that the ratio (w/w) of MenA saccharide:MenC saccharide is >1.

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Patent Owner(s)

  • GLAXOSMITHKLINE BIOLOGICALS SA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Costantino, Paolo Siena, IT 53 308

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