Antibodies to MUC16 and methods of use thereof

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United States of America Patent

PATENT NO 9790283
SERIAL NO

14850675

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Abstract

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The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to a polypeptide, or antigenic portion thereof, wherein the polypeptide is selected from a) MUC16 ectodomain polypeptide, b) MUC16 cytoplasmic domain polypeptide, and c) MUC16 extracellular domain polypeptide that contains a cysteine loop polypeptide. The invention's antibodies and compositions containing them are useful in diagnostic and therapeutic applications for diseases in which MUC16 is overexpressed, such as cancer.

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Patent Owner(s)

Patent OwnerAddress
MEMORIAL SLOAN KETTERING CANCER CENTER1275 YORK AVENUE NEW YORK NY 10065

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Spriggs, David New York, US 16 71
Thapi, Dharmarao Bayside Hills, US 8 34

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