Protease-based biosensor

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United States of America Patent

PATENT NO 9791436
APP PUB NO 20150226731A1
SERIAL NO

14427982

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Abstract

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A biosensor molecule comprises: a protease amino acid sequence; at least one sensor comprising at least one sensor amino acid sequence which is responsive to at least one target molecule; and an inhibitor of the protease activity of said protease amino acid sequence; wherein the biosensor is switchable from a protease active to a protease inactive state, or from a protease inactive to a protease active state when said sensor responds to said target molecule. The biosensor protease may be a protease of a virus such as a Potyvirus or a Flavivirus wherein the inhibitor is an autoinhibitory peptide derived from the virus. The biosensor may respond to the target molecule allosterically or may be cleaved by a target protease molecule.

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Patent Owner(s)

Patent OwnerAddress
THE UNIVERSITY OF QUEENSLANDQUEENSLAND

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Alexandrov, Kirill St Lucia, AU 8 9
Stein, Viktor St Lucia, AU 4 3
Trau, Matt St Lucia, AU 6 9

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