Method of screening for a compound for inhibitory activity of FN14-tweak interaction

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United States of America Patent

PATENT NO 9797882
SERIAL NO

14904363

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Abstract

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The present disclosure is directed to methods of screening a compound for modulating activity at a TNF-like weak inducer of apoptosis (TWEAK) binding site on a cysteine-rich domain (CRD) of fibroblast growth factor-inducible 14 (Fn14). The present disclosure also provides heterocyclic compounds and pharmaceutically acceptable salts thereof and methods for the prevention, treatment, and amelioration of cell proliferative disorders with these compounds.

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THE TRANSLATIONAL GENOMICS RESEARCH INSTITUTE445 N FIFTH STREET SUITE 600 PHOENIX AS 85004

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dhruv, Harshil Phoenix, US 7 31
Meurice, Nathalie Scottsdale, US 2 20
Tran, Nhan Phoenix, US 19 508
Yin, Hongwei Phoenix, US 12 25

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