Protecting groups for “Z nucleotide” and methods thereof

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United States of America Patent

PATENT NO 9802975
APP PUB NO 20150353594A1
SERIAL NO

14724613

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Abstract

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The present disclosure provides nucleoside compounds and oligonucleotides including an unnatural 6-amino-2-pyridone heterocyclic base where the 6-amino and 2-positions are protected. The 2-position of the heterocyclic base can be protected with an acyl-oxy-methyl protecting group. In some embodiments, the protected heterocyclic base has the following structure where AcOM is an acetyl-oxy-methyl group and R is a ribose or deoxyribose sugar:

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Patent Owner(s)

Patent OwnerAddress
AGILENT TECHNOLOGIES INC5301 STEVENS CREEK BLVD MS 1A-PB SANTA CLARA CA 95051-7201

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dellinger, Douglas J Boulder, US 83 3523
Lunstad, Benjamin D Santa Clara, US 3 1

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