Modified saccharides

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United States of America Patent

PATENT NO 9803030
SERIAL NO

12448709

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Abstract

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Modified capsular saccharides comprising a blocking group at a hydroxyl group position on at least one of the monosaccharide units of the corresponding native capsular saccharide, wherein the blocking group is of the formula (Ia) or (Ib): —OX—Y (Ia) or —O—R1 (Ib) wherein X is C(O), S(O) or SO2; Y is NR1R2 or R3; R1 is C1-6 alkyl substituted with 1, 2 or 3 groups independently selected from hydroxyl, sulphydryl and amine; R2 is H or C1-6 alkyl; and R3 is C1-6 alkyl; processes for modifying a capsular saccharide with the blocking groups; saccharide-protein conjugates comprising the modified capsular saccharide; processes for making the saccharide-protein conjugates, pharmaceutical compositions comprising the modified capsular saccharides and/or saccharide-protein conjugates; and methods and uses of the same.

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Patent Owner(s)

  • GLAXOSMITHKLINE BIOLOGICALS SA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bardotti, Angela Siena, IT 8 23
Berti, Francesco Siena, IT 50 157
Costantino, Paolo Siena, IT 53 308

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