Flagellar and needle complex (injectosome) loop as anti bacterial drug target
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Nov 7, 2017
Grant Date -
Jan 7, 2016
app pub date -
Feb 27, 2014
filing date -
Feb 27, 2013
priority date (Note) -
In Force
status (Latency Note)
Importance
Abstract
The present invention relates to a method for screening a compound that inhibits secretion of toxins into host-cell cytoplasm by virulent bacteria using a needle type III secretion system. The compound of the invention is selected by screening for a compound which interacts with a loop region of the cytoplasmic domain of the membrane protein FlhB from Salmonella typhimurium or a paralog thereof. Compositions including the compound of the invention, use of the compound, and methods of treating disorders caused by virulent bacteria are also provided.
First Claim
Family
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Cited Art Landscape
Patent Citation Ranking
Advertisement
Advertisement
Advertisement
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully