Compositions and methods for efficacious and safe delivery of siRNA using specific chitosan-based nanocomplexes

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United States of America Patent

PATENT NO 9809821
SERIAL NO

14955806

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Abstract

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There is disclosed a composition and a method for the efficient delivery of a therapeutic RNAi-inducing nucleic acid to cells both in vitro and in vivo through specific formulations of a non viral delivery system using chitosans. Particularly, the composition contains a nucleic acid and a specific chitosan that has the following physico-chemical properties: a number-average molecular weight between 5 kDa and 200 kDa, a degree of deacetylation between 80% and 95% and a chitosan amine to nucleic acid phosphate ratio below 20.

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Patent Owner(s)

Patent OwnerAddress
POLYVALOR LIMITED PARTNERSHIPMONTRÉAL QC H3B 0E7

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Buschmann, Michael D Montreal, CA 20 673
Merzouki, Abderrazzak Laval, CA 4 8

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