Triptolide derivatives and preparation method and use thereof

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United States of America Patent

PATENT NO 9809822
SERIAL NO

15100092

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Abstract

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Tripyolide-nucleic acid aptamer derivatives, a preparation method and use thereof are shown. The structure of the triptolide-nucleic acid aptamer derivatives is as shown by formula I, wherein the definitions of R1-R7, G, A, B, M, Z and X are described. The present invention uses a nucleic acid aptamer and triptolide or modified compounds thereof as the starting materials, and introduces a linking group A at the C-14 hydroxyl group, epoxy groups and five-membered ring lactones in triptolide, then connects it to a nucleic acid aptamer B, and obtains the triptolide-nucleic acid aptamer derivatives. The triptolide-nucleic acid aptamer derivatives of the present invention have the characteristics of good targeting, a high anti-cancer activity, low toxicity and side effects, good water solubility and high bioavailability, and the preparation method of the present invention is scientific and reasonable and has a controllable quality and good repeatability, and is thereby suitable for production.

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Patent Owner(s)

Patent OwnerAddress
HONG KONG BAPTIST UNIVERSITYKOWLOON TONG KOWLOON HONG KONG

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Liu, Biao Kowloon, HK 80 169
Lu, Aiping Kowloon, HK 27 7
Lu, Cheng Kowloon, HK 107 810
Lu, Jun Kowloon, HK 515 16290
Wang, Cheng Kowloon, HK 498 3753
Zhang, Ge Kowloon, HK 37 76

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