Targeting lipids

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United States of America Patent

PATENT NO 9814777
APP PUB NO 20140179761A1
SERIAL NO

14060353

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Abstract

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The present invention provides targeting lipids of structure

description='In-line Formulae' end='lead'L100-linker-L101  (CI),description='In-line Formulae' end='tail'

where L100 is a lipid, lipophile, alkyl, alkenyl or alkynyl, L101 is a ligand or —CH2CH2(OCH2CH2)pO(CH2)qCH2-ligand, p is 1-1000, and q is 1-20. In addition, the invention provides compositions and methods for the delivery of therapeutic agents to cells. In particular, these include novel lipids and nucleic acid-lipid particles that provide efficient encapsulation of nucleic acids and efficient delivery of the encapsulated nucleic acid to cells in vivo.

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Patent Owner(s)

Patent OwnerAddress
ARBUTUS BIOPHARMA CORPORATION25TH FLOOR 700 WEST GEORGIA STREET VANCOUVER BC V7Y 1B3

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Jayaraman, Muthusamy Cambridge, US 107 3970
Manoharan, Muthiah Cambridge, US 491 18658
Nair, Jayaprakash K Cambridge, US 63 214
Rajeev, Kallanthottathil G Cambridge, US 260 8660

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