Progenitor endothelial cell capturing with a drug eluting implantable medical device

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United States of America Patent

PATENT NO 9821093
SERIAL NO

13868938

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Abstract

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A medical device for implantation into vessels or luminal structures within the body is provided, which stimulates positive blood vessel remodeling. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as a peptide, an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

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Patent Owner(s)

Patent OwnerAddress
ORBUSNEICH MEDICAL PTE LTDSINGAPORE 338729

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Cottone,, Jr Robert John Davie, US 13 153
Parker, Sherry Sunrise, US 7 197
Rowland, Stephen M Miami, US 26 2422

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