Aryl-substituted imidazoles

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United States of America Patent

PATENT NO 9822100
SERIAL NO

14991744

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Abstract

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The compounds of the invention are antagonists of MDM2 and MDMX, with excellent specificity for MDM2 and MDMX over other proteins, and with selective binding affinity to MDMX over MDM2. The compounds can therefore regulate p53 activity and treat a variety of cancers. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

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Patent Owner(s)

Patent OwnerAddress
ST JUDE CHILDREN'S RESEARCH HOSPITALMEMPHIS TN 38105

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bashford, Donald Memphis, US 5 23
Bharatham, Nagakumar Memphis, US 11 22
Dyer, Michael Memphis, US 6 26
Ferreira, Antonio Memphis, US 9 137
Finch, Kristin Memphis, US 4 21
Guy, R Kiplin Memphis, US 16 61
Kriwacki, Richard Memphis, US 9 64
Min, Jaeki Memphis, US 37 190
Min, Lie Memphis, US 7 54
Roy-Appa, Grace Memphis, US 4 21
Young, Brandon Memphis, US 11 31
Zhang, Yiqun Memphis, US 25 60

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