High affinity NY-ESO T cell receptors

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United States of America Patent

PATENT NO 9822163
SERIAL NO

15291540

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Abstract

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The present invention provides T cell receptors (TCRs) having the property of binding to SLLMWITQC-HLA-A*0201, the SLLMWITQC SEQ ID NO:126 peptide being derived from the NY-ESO-1 protein which is expressed by a range of tumour cells. The TCRs have a KD for the said peptide-HLA complex of less than or equal to 1 μM and/or have an off-rate (koff) of 1×10−3 S−1 or slower.

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Patent Owner(s)

Patent OwnerAddress
ADAPTIMMUNE LIMITEDABINGDON OXFORDSHIRE OX14 4RX

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Boulter, Jonathan Michael Abingdon, GB 18 163
Dunn, Steven Mark Abingdon, GB 12 113
Jakobsen, Bent Karsten Abingdon, GB 65 575
Li, Yi Abingdon, GB 871 4890
Molloy, Peter Eamon Abingdon, GB 28 124

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