Compositions and methods for inhibiting expression of the PCSK9 gene

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United States of America Patent

PATENT NO 9822365
SERIAL NO

15005933

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Abstract

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The invention relates to a double-stranded ribonucleic acid (dsRNA) for inhibiting the expression of the PCSK9 gene (PCSK9 gene), comprising an antisense strand having a nucleotide sequence which is less that 30 nucleotides in length, generally 19-25 nucleotides in length, and which is substantially complementary to at least a part of the PCSK9 gene. The invention also relates to a pharmaceutical composition comprising the dsRNA together with a pharmaceutically acceptable carrier and method for treating diseases caused by PCSK9 gene expression.

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Patent Owner(s)

Patent OwnerAddress
ALNYLAM PHARMACEUTICALS INC675 WEST KENDALL STREET HENRI A TERMEER SQUARE CAMBRIDGE MA 02142

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Akinc, Akin Needham, US 113 3427
Bramlage, Birgit Kulmbach, DE 38 815
Fitzgerald, Kevin Brookline, US 209 2389
Frank-Kamenetsky, Maria Brookline, US 50 1080
Kotelianski, Victor E Boston, US 21 343
Tan, Pamela Kulmbach, DE 90 1575

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