separatome-based protein expression and purification platform

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United States of America Patent

PATENT NO 9822371
SERIAL NO

15022852

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Abstract

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Provided is a separatome-based peptide, polypeptide, and protein expression and purification platform based on the juxtaposition of the binding properties of host cell genomic peptides, polypeptides, and proteins with the characteristics and location of the corresponding genes on the host cell chromosome of E. coli. The separatome-based protein expression and purification platform quantitatively describes and identifies priority deletions, modifications, or inhibitions of certain gene products to increase chromatographic separation efficiency, defined as an increase in column capacity, column selectivity, or both, with emphasis on the former. Moreover, the separatome-based protein expression and purification platform provides a computerized knowledge tool that, given separatome data, and a target recombinant peptide, polypeptide, or protein, intuitively suggests strategies facilitating efficient product purification. The separatome-based protein expression and purification platform is an efficient bioseparation system that intertwines host cell expression systems and chromatography.

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Patent Owner(s)

  • BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS;UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCATION;UNIVERSITY OF PITTSBURGH - OF THE COMMONWEALTH SYSTEM OF HIGHER EDUCTION

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Ataai, Mohammad M Pittsburgh, US 7 13
Bartlow, Patrick R Pittsburgh, US 7 13
Beitle, Robert R Little Rock, US 5 12
Brune, Ellen M Little Rock, US 7 13
Henry, Ralph L Little Rock, US 7 13

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