Hypo- and hyper-acetylated meningococcal capsular saccharides

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United States of America Patent

PATENT NO 9827301
APP PUB NO 20140234368A1
SERIAL NO

14267248

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Abstract

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Capsular saccharides derived from serogroups W135 and Y of Neisseria meningitidis have altered levels of O-acetylation at the 7 and 9 positions of their sialic acid residues, and can be used to make immunogenic compositions. Relative to unmodified native saccharides, derivatives of the invention are preferentially selected during conjugation to carrier proteins, and conjugates of the derivatives show improved immunogenicity compared to native polysaccharides.

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Patent Owner(s)

  • GLAXOSMITHKLINE BIOLOGICALS SA

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Berti, Francesco Siena, IT 50 157
Costantino, Paolo Siena, IT 53 308

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