Multi-stage bioreactor processes
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United States of America Patent
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Dec 5, 2017
Grant Date -
Apr 28, 2016
app pub date -
Oct 22, 2015
filing date -
Oct 22, 2014
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Abstract
Multi-stage, biological processes and systems for converting a C1 carbon source to desired end products are described. The processes comprise dividing a gaseous C1-containing substrate, in parallel, among multiple bioreactor stages. Liquid products are successively fed, in series, from a first bioreactor stage to downstream bioreactor stages. Operation can be simplified by avoiding the requirement for microorganism separation and recycle at each stage. In addition, overall vapor-liquid mass transfer for the combined stages is very favorable, leading to high end product productivity with comparably low byproduct metabolite productivity.
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