P2X4 receptor antagonist
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United States of America Patent
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Dec 12, 2017
Grant Date -
Aug 25, 2016
app pub date -
Jul 11, 2014
filing date -
Jul 12, 2013
priority date (Note) -
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status (Latency Note)
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Abstract
The present invention relates to a compound represented by the following general formula (II), wherein, in the formula, R1a to R6a represent hydrogen atom, an alkyl group having 1 to 8 carbon atoms, and the like, Xa represents C or N, Ya represents N or C(═O), provided that when Xa is C, Ya represents N, and when Xa is N, Ya represents C(═O), the double line consisting of the solid line and the broken line represents a single bond or double bond, Aa represents benzene ring, pyridine ring, and the like, Da represents tetrazole ring, imidazole ring, and the like, Ea represents —(CR9aR10a)p-Ta-, and Ga represents benzene ring, pyridine ring, and the like, which has a P2X4 receptor antagonistic activity.
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