CRISPR-based compositions and methods of use

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United States of America Patent

PATENT NO 9840702
SERIAL NO

14975709

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Abstract

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This invention pertains to modified compositions for use in CRISPR systems, and their methods of use. In particular, length-modified and chemically-modified forms of crRNA and tracrRNA are described for use as a reconstituted guide RNA for interaction with Cas9 of CRIPSR systems. The resultant length-modified and chemically-modified forms of crRNA and tracrRNA are economical to produce and can be tailored to have unique properties relevant to their biochemical and biological activity in the context of the CRIPSR Cas9 endonuclease system.

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Patent Owner(s)

Patent OwnerAddress
INTEGRATED DNA TECHNOLOGIES INC1710 COMMERCIAL PARK CORALVILLE IA 52241

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Behlke, Mark Aaron Coralville, US 74 956
Collingwood, Michael Allen North Liberty, US 23 144
Jacobi, Ashley Mae Tiffin, US 7 72
Rettig, Garrett Richard Coralville, US 17 120
Schubert, Mollie Sue Cedar Rapids, US 6 71

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