Indocyanine compound, synthesis method and purification method thereof, diagnostic composition using the indocyanine compound, and device for measuring biokinetics and device for visualizing circulation using the diagnostic composition

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United States of America Patent

PATENT NO 9844606
SERIAL NO

14616117

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Abstract

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The present invention aims at providing a novel indocyanine compound solving problems of conventionally used indocyanine green, such as solubility in water or physiological saline, a synthesis method and a purification method thereof, and a diagnostic composition including the novel indocyanine compound. Further, provided are a method for evaluating biokinetics of the novel indocyanine compound and a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, which utilize the diagnostic composition. Also, found are a novel indocyanine compound in which a hydrophobic moiety in a near-infrared fluorescent indocyanine molecule is included in a cavity of a cyclic sugar chain cyclodextrin to cover the hydrophobic moiety in the indocyanine molecule with the glucose, and a synthesis method and a purification method thereof. Furthermore, found are a method for fluorescence-imaging an organ other than liver by intravenous administration, a method for evaluating biokinetics of the novel indocyanine compound, a device for measuring biokinetics, and a method and a device for visualizing circulation of fluid such as blood in a living body, utilizing the diagnostic composition including the novel indocyanine compound.

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Patent Owner(s)

  • NATIONAL UNIVERSITY CORPORATION NAGOYA UNIVERSITY;NATIONAL UNIVERSITY CORPORATION MIE UNIVERSITY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Arai, Tetsuya Nagoya, JP 58 538
Hirata, Hitoshi Nagoya, JP 30 280
Teranishi, Katsunori Tsu, JP 5 12

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