Inhibitors of NEDD8-activating enzyme

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United States of America Patent

PATENT NO 9850214
SERIAL NO

14326051

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Abstract

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Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.

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Patent Owner(s)

Patent OwnerAddress
TAKEDA PHARMACEUTICAL COMPANY LIMITEDOSAKA-SHI OSAKA 541-0045

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
McCarron, Ashley Sue Bedford, US 3 22
Sells, Todd B Southborough, US 26 319
Stirling, Matthew Randolph, US 10 79
Stroud, Stephen G Medford, US 42 442

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