CD123 binding agents and uses thereof

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United States of America Patent

PATENT NO 9850310
SERIAL NO

14844194

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Abstract

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Provided herein are antibodies that immunospecifically bind to CD123. Also described are related polynucleotides capable of encoding the provided CD123-specific antibodies or antigen-binding fragments, cells expressing the provided antibodies or antigen-binding fragments, as well as associated vectors and detectably labeled antibodies or antigen-binding fragments. In addition, methods of using the provided antibodies are described. For example, the provided antibodies may be used to diagnose, treat, or monitor CD123-expressing cancer progression, regression, or stability; to determine whether or not a patient should be treated for cancer; or to determine whether or not a subject is afflicted with CD123-expressing cancer and thus may be amenable to treatment with a CD123-specific anti-cancer therapeutic, such as the multispecific antibodies against CD123 and CD3 described herein.

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Patent Owner(s)

  • JANSSEN PHARMACEUTICA NV

International Classification(s)

Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Attar, Ricardo Lawrenceville, US 21 313
Gaudet, Francois Princeton, US 16 104
Harman, Benjamin C Oaklyn, US 1 29
Li, Yingzhe Dresher, US 55 591
Luo, Jinquan Malvern, US 73 506
McDaid, Ronan Eagleville, US 6 47
Nemeth, Jennifer F Fort Washington, US 3 54
Pomerantz, Steven C Huntingdon Valley, US 2 34
Tam, Susan H Garnet Valley, US 11 476
Teplyakov, Alexey Phoenixville, US 39 218
Wheeler, John Downingtown, US 32 557
Wu, Sheng-Jiun Broomall, US 35 652

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