Complement component C5 iRNA compositions and methods of use thereof

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United States of America Patent

PATENT NO 9850488
SERIAL NO

14976261

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Abstract

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The invention relates to iRNA, e.g., double-stranded ribonucleic acid (dsRNA), compositions targeting the complement component C5 gene, and methods of using such iRNA, e.g., dsRNA, compositions to inhibit expression of C5 and to treat subjects having a complement component C5-associated disease, e.g., paroxysmal nocturnal hemoglobinuria.

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Patent Owner(s)

Patent OwnerAddress
ALNYLAM PHARMACEUTICALS INC675 WEST KENDALL STREET HENRI A TERMEER SQUARE CAMBRIDGE MA 02142-1110

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bettencourt, Brian Groton, US 134 658
Borodovsky, Anna Melrose, US 54 422
Butler, James Lynnfield, US 112 2166
Charisse, Klaus Acton, US 73 449
Fitzgerald, Kevin Brookline, US 209 2389
Foster, Donald Attleboro, US 35 131
Kuchimanchi, Satyanarayana Acton, US 61 396
Maier, Martin Belmont, US 260 4382
Manoharan, Muthiah Weston, US 491 18658
Rajeev, Kallanthottathil G Wayland, US 260 8660

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