Biological assay of peptidoglycans

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United States of America Patent

PATENT NO 9857355
SERIAL NO

14779353

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Abstract

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The present invention relates to a biological method for assaying peptidoglycans (PGN) in a sample, particularly a sample of glucose polymers. The PGN assay includes: a) treating the glucose polymer sample by sonication, heating, and/or alkalizing; b) placing the treated sample or a dilution thereof in contact with a recombinant cell expressing an exogenous TLR2 (toll-like receptor 2) and a reporter gene directly dependent on the signaling pathway associated with the TLR2. The reporter gene codes for a colored or fluorescent protein or for a protein the activity of which is measurable with or without a substrate; c) measuring the reporter gene signal; and d) determining the amount of PGN in the sample using a standard curve of the correlation between the amount or PGN and the strength of the reporter gene signal.

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Patent Owner(s)

  • ROQUETTE FRERES

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Allain, Fabrice Lille, FR 11 7
Bernard, Roselyne Lestrem, FR 5 3
Biguet, Marc Neuve Chapelle, FR 4 3
Carpentier, Mathieu Saint Andre lez Lille, FR 11 7
Denys, Agnès Lille, FR 6 2
Hacine-Gherbi, Héla Villeneuve d'Ascq, FR 4 2
Lanos, Pierre La Bassee, FR 20 20

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