Therapeutic compositions for neutralizing type I interferons, and methods of use

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United States of America Patent

PATENT NO 9861681
SERIAL NO

14785058

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Abstract

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The inventions describe here cover therapeutic compositions, and methods of use, for neutralizing Type I interferons in a mammal. The compositions contain a soluble Orthopoxvirus IFN-binding protein that is modified to remove the cell-binding region, and that specifically binds to Type I IFNs, and a pharmaceutically acceptable carrier or excipient. Another variation of the invention entails a novel IFN-binding protein that is modified to remove the cell-binding region and the signal sequence.

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Patent Owner(s)

  • THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE ARMY

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Golden, Joseph Hagerstown, US 5 18
Hooper, Jay New Market, US 10 40

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