Polymeric prodrug of disulfiram and application thereof

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United States of America Patent

PATENT NO 9861704
SERIAL NO

14962426

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Abstract

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Polymer/drug conjugates that can selectively target and kill cancer cells are described. Conjugates can include a copolymer formed by the reaction of a biocompatible hydrophilic component and a disulfiram derivative. The copolymer reaction product can include additional functional groups pendant to the backbone via a disulfide linkage, for instance copper chelators. The hydrophilic component can form the polymer backbone and/or can form hydrophilic pendant groups off of the backbone. Copper ions can be associated with the copolymer.

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Patent Owner(s)

Patent OwnerAddress
UNIVERSITY OF SOUTH CAROLINAOSBORNE ADMINISTRATION BUILDING SUITE 109 COLUMBIA SC 29208

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
He, Huacheng West Columbia, US 8 15
Xu, Peisheng Chapin, US 28 69

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