Label free molecular detection methods, systems and devices
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United States of America Patent
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Jan 9, 2018
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app pub date -
Jan 16, 2014
filing date -
Jan 16, 2013
priority date (Note) -
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Abstract
Methods, systems, and devices are disclosed for capturing, concentrating, isolating, and detecting molecules. In one aspect, a molecular probe device includes a molecular probe having a complimentary base pair region initially zipped and structured to include a binding agent to chemically attach the molecular probe to an outer surface of a magnetic bead, and a binding molecule to chemically attach the molecular probe to a substrate of a microfluidic device, in which the complimentary base pair region is configured to hybridize to a complementary nucleic acid sequence of a DNA or RNA molecule.
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