Conformational probes and methods for sequencing nucleic acids

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United States of America Patent

PATENT NO 9862998
SERIAL NO

15132662

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Abstract

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This disclosure provides a method of determining a sequence of nucleotides for a nucleic acid template. The method can include the steps of contacting the nucleic acid template with a conformationally labeled polymerase and at least four different nucleotide species under conditions wherein the conformationally labeled polymerase catalyzes sequential addition of the nucleotide species to form a nucleic acid complement of the nucleic acid template, wherein the sequential addition of each different nucleotide species produces a conformational signal change from the conformationally labeled polymerase and wherein the rate or time duration for the conformational signal change is distinguishable for each different nucleotide species; detecting a series of changes in the signal from the conformationally labeled polymerase under the conditions; and determining the rates or time durations for the changes in the signal, thereby determining the sequence of nucleotides for the nucleic acid template.

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Patent Owner(s)

  • ILLUMINA, INC.

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Chen, Cheng-Yao San Diego, US 55 680
He, Molly San Diego, US 76 1370
Kool, Eric Stanford, US 6 58
Pantoja, Rigo Carlsbad, US 22 373
Previte, Michael Carlsbad, US 93 991
Ronaghi, Mostafa San Diego, US 58 4261

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